28andHe
About the dataset
28andHe is a dense-sampling, deep phenotyping study to determine whether diurnal variation in steroid hormone concentrations in a male impacts large-scale brain network connectivity and whole-brain structure.
Participant: The participant is a right-handed Caucasian male, aged 26 years for duration of the study. The participant had no history of neuropsychiatric diagnosis, endocrine disorders, or prior head trauma. The participant gave written informed consent and the study was approved by the University of California, Santa Barbara Human Subjects Committee.
Study Design: The participant underwent daily testing for 30 consecutive days. Sessions occurred in the morning for the first 10 days, both morning and evening for the following 10 days, and in the evenings for the last 10 days, resulting in 40 sessions total. Each test session began with a daily questionnaire, followed by endocrine sampling at 7am (morning sessions) and at 8pm (evening sessions). The participant gave a 2mL saliva sample at each session, followed by a blood sample. On days with two sessions, the participant underwent one blood draw per day per safety guidelines. Morning endocrine samples were collected after at least 8 hours of overnight fasting, and evening endocrine samples were collected following an hour and a half of abstaining from consumption of food or drink (excluding water). The participant refrained from consuming caffeinated beverages before each morning session. The MRI session lasted one hour and consisted of structural and functional MRI sequences.
Behavioral Assessments: To monitor state-dependent mood and lifestyle measures throughout the two studies, the following scales (adapted to reflect the past 24 hours) were administered each session: Perceived Stress Scale (PSS; Cohen et al., 1983), Pittsburgh Sleep Quality Index (PSQI: Buysse et al., 1989), State-Trait Anxiety Inventory for Adults (STAI: Speilberger & Vagg, 1984), Profile of Mood States (POMS: Pollock et al., 1979), and Aggression Questionnaire (Buss & Perry, 1992). The questionnaire for the evening sessions excluded the PSQI to avoid redundancy. Behavioral data can be found under ‘participants.tsv’
| PI | Emily Jacobs | |
|---|---|---|
| Institution | University of California, Santa Barbara | |
| Study Website | 28andHe | |
| Data Descriptor Paper | https://doi.org/10.1523/JNEUROSCI.1856-23.2024 | |
| CUBIC Project | open-datasets | |
| DUA | None | |
| License | CC BY-NC-SA | |
| Sample Size | 1 | |
| Number of Sessions | 40 | |
| CuBIDS | false | |
| BABS | false | |
| Demographics | View available demographics data | |
| Average Age (y) | 26 | |
| % Female | 0 | |
| % Right Handed | 100 | |
| BIDS Dataset |
/cbica/projects/open-datasets/datasets/28andHe/dset
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FreeSurfer
v7.3.2
Run by fMRIPrep (40/40 complete) |
/cbica/projects/open-datasets/datasets/28andHe/derivatives/fmriprep/sourcedata/freesurfer
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fMRIprep
v25-0-0
(40/40 complete) |
/cbica/projects/open-datasets/datasets/28andHe/derivatives/fmriprep
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Funding
Ann S. Bowers Women’s Brain Health Initiative
UC Academic Senate
National Institutes of Health AG063843
Citations
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Grotzinger, H., Pritschet, L., Shapturenka, P., Santander, T., Murata, E. M., & Jacobs, E. G. (2024). Diurnal fluctuations in steroid hormones tied to variation in intrinsic functional connectivity in a densely sampled male. Journal of Neuroscience, 44(22).
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Murata, E. M., Pritschet, L., Grotzinger, H., Taylor, C. M., & Jacobs, E. G. (2024). Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male. Journal of Neuroscience, 44(38).