Shared AI2D Neuroimaging Data Resources

This resource is a pilot meant to jump-start a broader effort for datasharing at AI2D.

Many labs at Penn use the same large, publicly available neuroimaging datasets. Historically, each lab downloaded, processed, and maintained their own version of the data – resulting in duplicated efforts, wasted computational resources, and inefficient use of storage. The shared neuroimaging data resources provided by AI2D addresses these challenges by providing centralized access to many of the largest and most commonly used neuroimaging datasets. All datasets are curated, processed, and shared using a standardized workflow that includes widely-used tools developed by AI2D labs. The result? Larger scale, lower cost, and faster progress.

Currently Available Shared Neuroimaging Data Resources

Note: The Sample Size and Number of Sessions shown in the table below represent the full dataset. The number of completed sessions for each processing pipeline can be found on each study-specific page.

Dataset Age Range (y) Sample Size Number of Sessions Raw Processed
T1w fMRI dMRI fmap FreeSurfer DLMUSE RAVENS DLWMLS fMRIPrep XCP‑D QSIPrep QSIRecon
28andHe 26 1 40 ✅ ✅ NA ✅ ✅ NA NA NA ✅ NA NA NA
28andMe 23-24 1 60 ✅ ✅ NA ✅ ✅ NA NA NA ✅ NA NA NA
Action for Health in Diabetes Study (lookAHEAD) 54.10-84.08 311 311 ✅ ✅ NA NA NA ✅ ✅ ✅ NA NA NA NA
Action to Control Cardiovascular Risk in Diabetes (ACCORD) 54.7-79.3 629 1414 ✅ NA ✅ NA NA ✅ ✅ ✅ NA NA NA NA
Alzheimer's Disease Neuroimaging Initiative (ADNI) 55-90 2517 10913 ✅ NA NA NA NA ✅ ✅ ✅ NA NA NA NA
Alzheimer's Disease Neuroimaging Initiative - Department of Defense (ADNI-DOD) 50-90 275 537 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) 41.6-96 976 1981 ✅ NA NA NA NA ✅ ✅ ✅ NA NA NA NA
Baltimore Longitudinal Study of Aging (BLSA) 22-93 1152 4086 ✅ ✅ ✅ NA NA ✅ ✅ ✅ NA NA NA NA
Biomarkers of Cognitive Decline Among Normal Individuals (BIOCARD) 20.53-86.27 313 1171 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Brazil High Risk Cohort (BHRC) 6-14 610 907 ✅ ✅ NA NA ✅ NA NA NA ✅ ✅ NA NA
Canadian Biomarker Integration Network in Depression (CANBIND) 18-61 309 309 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Coordinate-MDD BlameMRI-DePredict 18-64 167 167 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Coronary Artery Risk Development in Young Adults (CARDIA) 42-61 882 2293 ✅ ✅ ✅ NA NA ✅ ✅ ✅ ✅ ✅ NA NA
Course and Outcome of Bipolar Youth (COBY) 18-32 93 93 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Depression Improvement Across Minnesota, Offering a New Direction (DIAMOND) 18-30 222 222 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Developmental Chinese Color Nest Project (dCCNP) 6.5-17.9 195 195 ✅ ✅ NA NA ✅ ✅ NA NA ✅ ✅ NA NA
Enhancing Neuro Imaging Genetics through Meta-Analysis (Enigma) 16-86 370 370 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) 18-65 329 329 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Federal Interagency TBI Research (FITBIR) 17.04-86 1500 3347 ✅ NA NA NA NA ✅ ✅ ✅ NA NA NA NA
Genomics Superstruct Project (GSP) 18-35 1570 1639 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Genomics of Alzheimer's Project (GAP) 18-62 218 218 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Harvard Brain Aging Study (HABS) 51-94 289 660 ✅ ✅ ✅ NA NA ✅ ✅ NA ✅ ✅ NA NA
Health & Aging Brain Study - Health Disparities (HABS-HD (HABLE)) 50-93 4160 6353 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) 33.2-72.4 263 263 ✅ ✅ ✅ NA NA ✅ ✅ ✅ NA NA NA NA
Healthy Brain Network (HBN) 5-22 3887 3887 ✅ ✅ ✅ ✅ ✅ ✅ NA NA ✅ ✅ ✅ ✅
Human Connectome Project - Aging (HCP-Aging) 36-90+ 725 725 ✅ ✅ ✅ ✅ NA ✅ ✅ NA NA NA NA NA
Human Connectome Project - Young Adult (HCP-YA) 22-37 1206 1206 NA NA NA NA NA ✅ ✅ NA NA ✅ NA ✅
Human Memory & Research Resource Center (HMRRC-SCU) 16-60 269 269 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
International Study to Predict Optimized Treatment in Depression (iSPOT-D) 18-65 202 202 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
King's College London Study (KCL) 18-43 40 40 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Korean Brain Aging Study for the Early Diagnosis & Prediction of Alzheimer's Disease (KBASE) 20-90 650 1198 ✅ ✅ ✅ NA NA ✅ ✅ NA NA NA NA NA
Longitudinal Imaging of Brain & Risk Study (LIBR) 18-55 296 296 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Manchester Brain Imaging Study (Manchester) 20-56 70 121 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Melbourne Ageing Study 13-57 328 328 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Memory & Aging Project – Rush Alzheimer's Disease Center (MAP - Rush) 58.81-100.19 1183 2710 ✅ NA ✅ NA NA ✅ ✅ NA NA NA NA NA
Midnight Scan Club 24-34 10 123 ✅ ✅ NA ✅ ✅ NA NA NA ✅ ✅ NA NA
Multi-Ethnic Study of Atherosclerosis (MESA) 59-99 1062 1062 ✅ ✅ ✅ NA NA ✅ ✅ ✅ NA NA NA NA
NKI Rockland Sample 6.2-85.6 1329 2306 ✅ ✅ ✅ NA ✅ ✅ NA NA ✅ ✅ ✅ ✅
National Alzheimer's Coordinating Center (NACC) 21-100 5004 6543 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Neural Modelling (cneuromod) variable variable variable ✅ ✅ NA ✅ ✅ NA NA NA ✅ NA NA NA
Open Access Series of Imaging Studies (OASIS) 21-95 2042 3518 ✅ ✅ ✅ ✅ NA ✅ ✅ ✅ ✅ ✅ NA NA
Philadelphia Neurodevelopmental Cohort (PNC) 8-23 1601 1601 ✅ ✅ ✅ ✅ ✅ ✅ NA NA ✅ ✅ ✅ ✅
Prediction of Depression Risk in Clinical Treatment (PReDICT) 19-64 122 122 ✅ ✅ NA NA NA ✅ ✅ NA NA NA NA NA
Prevention of Alzheimer's Disease (PreventAD) 55.17-84.25 344 1559 ✅ ✅ ✅ ✅ NA ✅ ✅ NA ✅ ✅ NA NA
Program of First Episode Psychosis Study (PAFIP) 17.28-54.5 316 316 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Psychosis Data from China Peking University 16-36 67 67 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Psychosis Data from China Tianji-Anning Hospital 14-59 210 210 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
Psychosis Data from China Xijing Hospital 18-44 48 48 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
STratifying Resilience and Depression Longitudinally (STRADL) 26-84 1080 1080 ✅ ✅ NA NA NA NA ✅ NA ✅ ✅ NA NA
Single-echo/multi-echo comparison pilot (Mobile Phenomics Pilot) 21-30 8 17 ✅ ✅ NA ✅ ✅ NA NA NA ✅ NA NA NA
Stanford Neurodevelopment Affect and Pyschopathology Laboratory (Standford SNAP) 19-58 110 110 ✅ ✅ NA NA NA ✅ ✅ NA ✅ ✅ NA NA
Study of Health in Pomerania (SHIP) 21-90 3312 3312 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Systolic Blood Pressure Intervention Trial (SPRINT) 50-90 788 1336 ✅ ✅ ✅ NA NA ✅ ✅ ✅ NA NA NA NA
UK Biobank 45-81 22308 42081 ✅ ✅ ✅ ✅ NA ✅ ✅ ✅ NA ✅ NA NA
University Medical Center Utrecht Brain Imaging Study (UMC-Utrecht) 16-67.49 832 832 ✅ NA NA NA NA ✅ NA NA NA NA NA NA
University of Pennsylvania Study (PENN) 23-92.22 1556 1556 ✅ ✅ NA NA NA ✅ ✅ ✅ NA NA NA NA
Washington Heights–Inwood Columbia Aging Project (WHICAP) 62-100 1019 1336 ✅ NA NA NA NA ✅ ✅ NA NA NA NA NA
Wisconsin Registry for Alzheimer's Prevention (WRAP) 45.4-77.7 272 735 ✅ NA NA NA NA ✅ ✅ ✅ NA NA NA NA
Women's Health Initiative Memory Study (WHIMS) 63-79 1430 2160 ✅ NA NA NA NA ✅ ✅ ✅ NA NA NA NA

NA = Not Available
✅ = Available