About the dataset

Primary description: Blood pressure management trial

The Systolic Blood Pressure Intervention Trial (SPRINT) is a randomized control trial designed to evaluate how intensive blood pressure treatment affects the cardiovascular system, kidneys, and brain. The clinical trial ran from 2010-2015, including brain MR imaging in a subset of N= 670 participants. MR data was collected at seven sites according to a standardized protocol. Non-imaging data from the SPRINT clinical trial is available through the NHLBI’s BIOLINCC [https://biolincc.nhlbi.nih.gov/studies/sprint/].
Study Systolic Blood Pressure Intervention Trial
Study Website SPRINT
Data Descriptor Paper https://jamanetwork.com/journals/jama/fullarticle/2747671
DUA https://biolincc.nhlbi.nih.gov/studies/sprint
Country/Region USA
Disease Tag multi_disease
Age (mean ± SD)
(Baseline) 		68.0 ± 8.6
Age Range
(Baseline) 		50-90
% Female 38.9
CUBIC Project /cbica/projects/sprint
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 788
N MR Sessions 1336
Diagnoses
AD
Value V01 V02
nan 765 512
MCI 18 28
AD 2 7
DLMUSE (v1.0.7)
(1336/1336 complete)
/cbica/projects/sprint/Pipelines/SPRINT_DLMUSE_2025/Results/DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(1334/1334 complete)
/cbica/projects/sprint/PIPELINES/SPRINT_3.5D_2020/Protocols/RAVENS
DLWMLS (v0.1.0)
(1328/1328 complete)
/cbica/projects/sprint/Pipelines/SPRINT_DLWMLS_2025/Results/SPRINT_DLWMLS_DLMUSE_Segmented_Volumes.csv
Non-Imaging Data
/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/SPRINT

Raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/dictionaries/SPRINT

Data dictionary of raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv

Data consolidated and harmonized in 2020.

This study: subset with df[df.Study == 'SPRINT']

README: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/README.md

Release Notes: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/Release_Notes.md

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'SPRINT']


Funding
The Systolic Blood Pressure Intervention Trial was funded by the NIH, including the National Heart, Lung, and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Aging, and the National Institute of Neurological Disorders and Stroke under contracts HHSN268200900040C, HHSN268200900046C, HHSN268200900047C, HHSN268200900048C, and HHSN268200900049C and interagency agreement A-HL-13-002-001. It was also supported in part with resources and use of facilities through the Department of Veterans Affairs. Azilsartan and chlorthalidone (combined with azilsartan) were provided by Takeda Pharmaceuticals International Inc. Computing resources were supported through 1S10OD023495-01, and additional support was provided through National Center for Advancing Translational Sciences clinical and translational science awards UL1TR000439 (awarded to Case Western Reserve University); UL1RR025755 (Ohio State University); UL1RR024134 and UL1TR000003 (University of Pennsylvania); UL1RR025771 (Boston University); UL1TR000093 (Stanford University); UL1RR025752, UL1TR000073, and UL1TR001064 (Tufts University); UL1TR000050 (University of Illinois); UL1TR000005 (University of Pittsburgh); 9U54TR000017-06 (University of Texas Southwestern Medical Center); UL1TR000105-05 (University of Utah); UL1 TR000445 (Vanderbilt University); UL1TR000075 (George Washington University); UL1 TR000002 (University of California, Davis); UL1 TR000064 (University of Florida); and UL1TR000433 (University of Michigan) and by National Institute of General Medical Sciences, Centers of Biomedical Research Excellence award NIGMS P30GM103337 (Tulane University).