About the dataset

Primary description: Health disparities and aging

The Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study is an ongoing longitudinal study of race and socioeconomic-related health disparities based in Baltimore. Brain MRI was introduced in the third wave of the HANDLS protocol, between the years 2009-2013. Data availability via submitted and reviewed proposals [https://handls.nih.gov/06Coll.htm].
Study Healthy Aging in Neighborhoods of Diversity Across the Life Span
Study Website HANDLS
Data Descriptor Paper https://doi.org/10.1097/PSY.0000000000000408
DUA https://handls.nih.gov/06Coll.htm
Country/Region USA
Disease Tag aging;cardiovascular
Age (mean ± SD) 52.8 ± 9.3
Age Range 33.2-72.4
% Female 54.5
CUBIC Project /cbica/projects/handls
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 263
N MR Sessions 263
Diagnoses
AD
Value V01
CN 233
DLMUSE (v1.0.7)
(259/259 complete)
/cbica/projects/handls/Pipelines/HANDLS_DLMUSE_2025/Results/DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(258/258 complete)
/cbica/projects/handls/Pipelines/HANDLS_3D_2021/Protocols/RAVENS
DLWMLS (v0.1.0)
(255/255 complete)
/cbica/projects/handls/Pipelines/HANDLS_DLWMLS_2025/Results/HANDLS_DLWMLS_DLMUSE_Segmented_Volumes.csv
Non-Imaging Data
/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/HANDLS

Raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv

Data consolidated and harmonized in 2020.

This study: subset with df[df.Study == 'HANDLS']

README: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/README.md

Release Notes: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/Release_Notes.md

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'HANDLS']


Funding
The Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Scan substudy was funded by NIA grants R01AG034161, P30AS028747-14S1, R56AG064088-01A1, and the NIA Intramural Research Program ZIAG000513.