Open Access Series of Imaging Studies

About the dataset

Primary description: Aging and Alzheimer’s neuroimaging

OASIS-3 is a longitudinal neuroimaging, clinical, cognitive, and biomarker dataset for normal aging and Alzheimer’s Disease. OASIS-3 is a retrospective compilation of data for 1378 participants that were collected across several ongoing projects through the WUSTL Knight ADRC over the course of 30years. OASIS-4 consists of a clinical cohort who was evaluated for memory disorders and dementia. OASIS-4 is a unique dataset and not an update to the OASIS-3. The OASIS datasets hosted by central.xnat.org provide the community with open access to a significant database of neuroimaging and processed imaging data across a broad demographic, cognitive, and genetic spectrum an easily accessible platform for use in neuroimaging, clinical, and cognitive research on normal aging and cognitive decline. All data is available via [www.oasis-brains.org].

Study Open Access Series of Imaging Studies

Study Website OASIS

Data Descriptor Paper https://doi.org/10.1162/jocn.2007.19.9.1498

DUA https://sites.wustl.edu/oasisbrains/home/access/

Country/Region USA

Disease Tag alzheimers;aging

Age (mean ± SD) 74.4 ± 11.0

% Female 53.9

CUBIC Project /cbica/projects/OASIS

PI for CUBIC Access Approval Christos Davatzikos

OASIS3

Diagnoses

Value	V01	V02	V03	V04	V05	V06	V07	V08	V09
CN	767	460	246	119	54	28	8	1
AD	223	52	12	6	2		1	1	1
dementia	56	28	15	8	4	1	1
early MCI	17	3				1	1
Lewy Body Dementia	12	2
nan	12	2	1	1	1
FTD	5	1
Vascular Dementia	3	2
PD	2

Hypertension

Value	V01	V02	V03	V04	V05	V06	V07	V08	V09
Normal	463	214	100	40	17	7	2	1
Stage2	415	208	114	49	17	4	2	1	1
nan	204	116	51	42	25	18	6
Remote/inactive	15	12	9	3	2	1	1

Diabetes

Value	V01	V02	V03	V04	V05	V06	V07	V08	V09
Normal	793	391	190	82	34	12	5	2	1
nan	205	113	51	42	25	18	6
Diabetic	95	45	31	10	2
Remote/inactive	4	1	2

Hyperlipidemia

Value	V01	V02	V03	V04	V05	V06	V07	V08	V09
nan	1077	547	274	133	60	30	11	2	1
Positive/present	12	2
Negative/absent	8	1		1	1

TBI

Value	V01	V02	V03	V04	V05	V06	V07	V08	V09
nan	1077	547	274	133	60	30	11	2	1
Chronic Deficit: No; Brief Unconsciousness: No; Extended Unconsciousness: No	16	3		1	1
Chronic Deficit: No; Brief Unconsciousness: Remote/Inactive; Extended Unconsciousness: No	2
Chronic Deficit: NA; Brief Unconsciousness: NA; Extended Unconsciousness: NA	1
Chronic Deficit: No; Brief Unconsciousness: NA; Extended Unconsciousness: NA	1

Psychological Disorder

Value	V01	V02	V03	V04	V05	V06	V07	V08	V09
nan	1077	547	274	133	60	30	11	2	1
0.0	18	3		1	1
1.0	1
2.0	1

Age Range
(Baseline) 42-95

N Subjects 1379

N MR Sessions 2842

DLMUSE (v1.0.7)
(2162/2162 complete)

/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_DLMUSE_2025/Results/DLMUSE_Volumes.csv

RAVENS (DRAMMS-1.4.1)
(3382/3382 complete)

/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_3.5D_2020/Protocols/RAVENS

DLWMLS (v0.1.0)
(736/736 complete)

/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_DLWMLS_2025/Results/OASIS3_DLWMLS_DLMUSE_Segmented_Volumes.csv

fMRIPrep (23.1.3)
(2406/2842 complete)

/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_fMRI_Sep2023/Protocols

/opt/conda/envs/fmriprep/bin/fmriprep \
  /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Data/Init_Downloaded/scans/All/batch_<batch_number>/ \
  /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Protocols/ \
  participant \
  --participant_label <subid> \
  --fs-license-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/license.txt \
  --fs-no-reconall \
  --output-spaces MNI152NLin2009cAsym:res-2 \
  --bids-filter-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/bids_filter.json \
  --debug all

XCP-D (0.7.1rc6)
(1789/2842 complete)

/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_fMRI_Sep2023/Protocols/XCP

/usr/local/miniconda/bin/xcp_d \
  /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Protocols/batch_<batch_number> \
  /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Protocols/XCP/batch_<batch_number> \
  participant \
  --participant_label <subid> \
  --bids-filter-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/bids_filter.json \
  --input-type fmriprep \
  -p 36P \
  --work-dir /cbica/home/srinivad/Projects/2023_OASIS_BIDS/ \
  --motion-filter-type lp \
  --band-stop-min 6 \
  --motion-filter-order 4 \
  --despike \
  --fd-thresh 0 \
  --lower-bpf 0.01 \
  --upper-bpf 0.08 \
  --bpf-order 2 \
  --head-radius auto \
  --dummy-scans auto \
  --min-coverage 0.5 \
  --smoothing 0 \
  --fs-license-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/license.txt

Non-Imaging Data

/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/MESA/OASIS3

Raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/dictionaries/KBASE/OASIS3

Data dictionary of raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv

Data consolidated and harmonized in 2020.

This study: subset with df[df.Study == 'OASIS3']

README: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/README.md

Release Notes: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/Release_Notes.md

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'OASIS3']

OASIS4

Diagnoses

Value	V01	V02	V03
AD	300	2
dementia	119	2
nan	64	4
MCI	47	1
CN	45
other	25	1
FTD	21	1
Vascular Dementia	15	1	1
Lewy Body Dementia	11
early MCI	7

Age Range
(Baseline) 21-94

N Subjects 663

N MR Sessions 676

DLMUSE (v1.0.7)
(671/671 complete)

/cbica/projects/OASIS/OASIS4/Pipelines/OASIS4_DLMUSE_2025/Results/DLMUSE_Volumes.csv

RAVENS (DRAMMS-1.4.1)
(671/671 complete)

/cbica/projects/OASIS/OASIS4/Pipelines/OASIS4_3.5D_2022/Protocols/RAVENS