About the dataset

Primary description: Aging and Alzheimer’s neuroimaging

OASIS-3 is a longitudinal neuroimaging, clinical, cognitive, and biomarker dataset for normal aging and Alzheimer’s Disease. OASIS-3 is a retrospective compilation of data for 1378 participants that were collected across several ongoing projects through the WUSTL Knight ADRC over the course of 30years. OASIS-4 consists of a clinical cohort who was evaluated for memory disorders and dementia. OASIS-4 is a unique dataset and not an update to the OASIS-3. The OASIS datasets hosted by central.xnat.org provide the community with open access to a significant database of neuroimaging and processed imaging data across a broad demographic, cognitive, and genetic spectrum an easily accessible platform for use in neuroimaging, clinical, and cognitive research on normal aging and cognitive decline. All data is available via [www.oasis-brains.org].

Study Open Access Series of Imaging Studies
Study Website OASIS
Manuscript https://doi.org/10.1162/jocn.2007.19.9.1498
DUA https://sites.wustl.edu/oasisbrains/home/access/
Country/Region USA
Disease Tags alzheimers
Age (mean ± SD) 74.4 ± 11.0
% Female 53.9
CUBIC Project /cbica/projects/OASIS
OASIS3
Age Range 42-95
N Subjects 1379
N MR Sessions 2842
DLMUSE (version ???)
(2162/2842 complete)
/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_DLMUSE_2025/Results/DLMUSE_Volumes.csv
DLWMLS (version ???)
(736/2842 complete)
/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_DLWMLS_2025/Results/OASIS3_DLWMLS_DLMUSE_Segmented_Volumes.csv
fMRIPrep (23.1.3)
(2406/2842 complete)
/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_fMRI_Sep2023/Protocols
/opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Data/Init_Downloaded/scans/All/batch_<batch_number>/ \ /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Protocols/ \ participant \ --participant_label <subid> \ --fs-license-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/license.txt \ --fs-no-reconall \ --output-spaces MNI152NLin2009cAsym:res-2 \ --bids-filter-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/bids_filter.json \ --debug all
XCP-D (0.7.1rc6)
(1789/2842 complete)
/cbica/projects/OASIS/OASIS3/Pipelines/OASIS3_fMRI_Sep2023/Protocols/XCP
/usr/local/miniconda/bin/xcp_d \ /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Protocols/batch_<batch_number> \ /cbica/home/srinivad/Projects/2023_OASIS_BIDS/Protocols/XCP/batch_<batch_number> \ participant \ --participant_label <subid> \ --bids-filter-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/bids_filter.json \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/home/srinivad/Projects/2023_OASIS_BIDS/ \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/home/srinivad/Projects/2023_OASIS_BIDS/license.txt
OASIS4
Age Range 21-94
N Subjects 663
N MR Sessions 676
DLMUSE (version ???)
(671/676 complete)
/cbica/projects/OASIS/OASIS4/Pipelines/OASIS4_DLMUSE_2025/Results/DLMUSE_Volumes.csv


Funding
Data were provided [in part] by OASIS OASIS-3: Principal Investigators: T. Benzinger, D. Marcus, J. Morris; NIH P50 AG00561, P30 NS09857781, P01 AG026276, P01 AG003991, R01 AG043434, UL1 TR000448, R01 EB009352. AA was funded through grants 191026.