About the dataset

The Huaxi MR Research Center (HMRRC) cohort is comprised of first episode MDD medication-naïve and matched control. All participants receive baseline MRI scans. For more information, see https://doi.org/10.1186/s12888-022-04509-7.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.
Study Human Memory & Research Resource Center (SCU)
Data Descriptor Paper https://cdnsciencepub.com/doi/10.1503/jpn.170112
DUA Please contact Dr. Christos Davatzikos to obtain the DUA for the derived data and request an introduction to the study PI to obtain the DUA for the raw data.
Country/Region China
Disease Tag depression
Age (mean ± SD) 31.4 ± 11.4
Age Range 16-60
% Female 56.1
CUBIC Project /cbica/projects/MultisiteMD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 269
N MR Sessions 269
SCU-Set1
DLMUSE (v1.0.7)
(70/70 complete)
/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/SCU-Set1/Results/SCU-Set1_DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(70/70 complete)
/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/SCU-Set1
fMRIPrep (23.1.3)
(70/269 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set1/Pipelines/SCU-Set1_fMRI_2024/Protocols
/opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set1/Pipelines/SCU-Set1_fMRI_2024/Data/HC/ \ /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/fMRIPrep/SCU-Set1_fMRI_2025/Protocols/HC \ participant \ --participant_label 01 \ --skip-bids-validation \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set1/Pipelines/SCU-Set1_fMRI_2024/license.txt \ --fs-no-reconall \ --use-syn-sdc warn \ --output-spaces MNI152NLin2009cAsym:res-2 \ --debug all
XCP-D (0.7.1rc6)
(70/269 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set1/Pipelines/SCU-Set1_fMRI_2024/Protocols/XCP
/usr/local/miniconda/bin/xcp_d \ /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/fMRIPrep/SCU-Set1_fMRI_2025/Protocols/HC/ \ /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/XCP-D/SCU-Set1_fMRI_2025/Protocols/XCP/HC/ \ participant \ --participant_label 01 \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/XCP-D/SCU-Set1_fMRI_2025/Protocols/work/ \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set1/Pipelines/SCU-Set1_fMRI_2024/license.txt
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.
SCU-Set2
DLMUSE (v1.0.7)
(199/199 complete)
/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/SCU-Set2/Results/SCU-Set2_DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(199/199 complete)
/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/SCU-Set2
fMRIPrep (23.1.3)
(199/269 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set2/Pipelines/SCU-Set2_fMRI_2024/Protocols
/opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set2/Pipelines/SCU-Set2_fMRI_2024/Data/HC/ \ /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/fMRIPrep/SCU-Set2_fMRI_2025/Protocols/HC \ participant \ --participant_label NC002 \ --skip-bids-validation \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set2/Pipelines/SCU-Set2_fMRI_2024/license.txt \ --fs-no-reconall \ --use-syn-sdc warn \ --output-spaces MNI152NLin2009cAsym:res-2 \ --debug all
XCP-D (0.7.1rc6)
(199/269 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set2/Pipelines/SCU-Set2_fMRI_2024/Protocols/XCP
/usr/local/miniconda/bin/xcp_d \ /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/fMRIPrep/SCU-Set2_fMRI_2025/Protocols/HC/ \ /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/XCP-D/SCU-Set2_fMRI_2025/Protocols/XCP/HC/ \ participant \ --participant_label NC002 \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/home/kodibaga/COORDINATE_MDD/coordinate_mdd_sf_2025/Preprocessing/XCP-D/SCU-Set2_fMRI_2025/Protocols/work/ \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/SCU-Set2/Pipelines/SCU-Set2_fMRI_2024/license.txt
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.


Funding
This work was supported by the Natural Science Foundation of China (grant nos. 81401479, 81671767, 91432115, 81225012, 81621003, 81220108013, 81227002, 81620108016, 31521063 and 81030027), the Beijing Natural Science Foundation (grant nos. Z151100003915082, Z161100000216125 and Z161100000216152), the Fundamental Research Funds for the Central Universities (grant nos. 2015KJJCA13 and 2017XTCX04), the Chinese Postdoctoral Science Foundation (grant no. 2015M582554), the Changjiang Scholar Professorship Award (award no. T2015027 and T2014190) and the Sichuan Provincial Health and Family Planning Commission (grant no. 150251). Q. Gong also acknowledges the support provided by his CMB Distinguished Professorship Award (award no. F510000/G16916411) administered by the Institute of International Education, USA.