Program of First Episode Psychosis Study
About the dataset
Primary description: First-episode psychosis cohort
PAFIP is an early psychosis research and clinical intervention program based at the University Hospital Marqués de Valdecilla in Santander, Spain. It focuses on first-episode psychosis (FEP), especially non-affective psychoses such as schizophrenia spectrum disorders in people with their first psychotic episode.
The study is part of the PHENOM consortium. For more information, see: https://doi.org/10.1038/s41380-023-02069-0 and https://doi.org/10.1093/brain/awaa025. The PHENOM (Psychosis Heterogeneity Evaluated Via Dimensional Neuroimaging) consortium is an international consortium pooling MRI and clinical data across several institutions world-wide. The focus on the consortium is to study the use of machine learning and MRI as a means for deriving personalized imaging signatures of schizophrenia, and of predicting future clinical progression. An associated goal is to use state of the art weakly supervised machine learning methods to dissect neuroanatomical heterogeneity in psychosis. In addition to offering healthy control subjects at younger ages, this consortium helps establish imaging signatures of psychosis into NiChart.
The study is part of the PHENOM consortium. For more information, see: https://doi.org/10.1038/s41380-023-02069-0 and https://doi.org/10.1093/brain/awaa025. The PHENOM (Psychosis Heterogeneity Evaluated Via Dimensional Neuroimaging) consortium is an international consortium pooling MRI and clinical data across several institutions world-wide. The focus on the consortium is to study the use of machine learning and MRI as a means for deriving personalized imaging signatures of schizophrenia, and of predicting future clinical progression. An associated goal is to use state of the art weakly supervised machine learning methods to dissect neuroanatomical heterogeneity in psychosis. In addition to offering healthy control subjects at younger ages, this consortium helps establish imaging signatures of psychosis into NiChart.
| Study | Program for the care of First Episode Psychosis Study | |
|---|---|---|
| Data Descriptor Paper | https://doi.org/10.1016/j.eurpsy.2018.03.003 | |
| DUA | Please contact Dr. Christos Davatzikos to obtain the DUA for the derived data and request an introduction to the study PI to obtain the DUA for the raw data. | |
| Country/Region | Spain | |
| Disease Tag | psychosis | |
| Age (mean ± SD) | 30.0 ± 8.4 | |
| Age Range | 17.28-54.5 | |
| % Female | 39.2 | |
| CUBIC Project | /cbica/projects/PsychAnalysis |
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| PI for CUBIC Access Approval | Christos Davatzikos | |
| N Subjects | 316 | |
| N MR Sessions | 316 | |
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DLMUSE
(v1.0.7)
(316/316 complete) |
/cbica/projects/PsychAnalysis/Pipelines/PHENOM_DLMUSE_2025/PAFIP/Results/PAFIP_DLMUSE_Volumes.csv
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| Non-Imaging Data |
Contact Mathilde Antoniades to request access to the non-imaging data. /cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv
Data consolidated and harmonized in 2026. This study: subset with |
Funding
The study was carried out at the Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain, under the following grant supports: Plan Nacional de Drogas Research (2005-Orden sco/3246/2004); SENY Fundació (CI 2005–0308007); and Fundación Marqués de Valdecilla (API07/011); Gerencia Regional de Salud de Castilla y León (INT/M/04/17)