About the dataset

Primary description: Kings College London cohort

The Kings College London is comprised of four studies and involves an eight week treatment protocol of the serotonin-norepinephrine reuptake inhibitors (SNRI) duloxetine. MRI was obtained at baseline, and weeks two and eight for both those with MDD and healthy participants. For more information, see: https://doi.org/10.1192/bjpo.bp.115.002493 and https://doi.org/10.1186/s12888-022-04509-7.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.
Study King’s College London Study
Data Descriptor Paper https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2727131
DUA Please contact Dr. Christos Davatzikos to obtain the DUA for the derived data and request an introduction to the study PI to obtain the DUA for the raw data.
Country/Region UK
Disease Tag depression
Age (mean ± SD) 29.8 ± 6.6
Age Range 18-43
% Female 90
CUBIC Project /cbica/projects/MultisiteMD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 40
N MR Sessions 40
DLMUSE
(40/40 complete)
/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/KCL-BUD/Results/KCL-BUD_DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(40/40 complete)
/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/KCL-BUD
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'KCL-BUD']


Funding
This research was supported by the National Institute of Mental Health (grant K23MH108707 to Dr Aupperle and grant R21MH113871 to Dr Savitz); the Laureate Institute for Brain Research, National Institute of General Medical Sciences (grant P20GM121312 to Dr Paulus); and the Brain and Behavior Research Foundation (National Alliance for Research on Schizophrenia & Depression grant YI 23850 to Dr Savitz).