About the dataset

The Course and Outcome of Bipolar Youth (COBY) study (https://doi.org/10.1176/appi.ajp.2009.08101569) followed 413 children and adolescents (ages 7–17) diagnosed with bipolar I (n=244), bipolar II (n=28), or bipolar not otherwise specified (NOS) (n=141), recruited largely from outpatient clinics at Pittsburgh, Brown, and UCLA. Clinical symptoms were tracked retrospectively with the Longitudinal Interval Follow-up Evaluation about every 9 months over a 4-year period. The primary analyses focused on recovery rates, recurrence, and detailed week-by-week symptomatic course.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.
Study Course and Outcome of Bipolar Youth
Study Website COBY
Data Descriptor Paper https://pubmed.ncbi.nlm.nih.gov/19448190/
DUA https://nda.nih.gov/edit_collection.html?id=2392
Disease Tag bipolar
Age (mean ± SD) 25.0 ± 4.3
Age Range 18-32
% Female 54.3
CUBIC Project /cbica/projects/MultisiteMD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 93
N MR Sessions 93
DLMUSE
(92/92 complete)
/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/COBY/Results/COBY_DLMUSE_Volumes.csv
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'COBY']


Funding
MH59929 (Dr Birmaher), MH59977 (Dr Strober), and MH59691 (Dr Keller) from the National Institute of Mental Health, Rockville, Md.