About the dataset

Primary description: Women’s cognitive aging and menopause

Brain MRI scans were obtained in a subset of 1,403 women aged 71–89 years who participated in the Women’s Health Initiative Memory Study (WHIMS). WHIMS is an ancillary study to the Women’s Health Initiative, which consisted of two randomized, placebo-controlled trials: 0.625 mg conjugated equine estrogens (CEE) with or without 2.5 mg medroxyprogesterone acetate (MPA) in one daily tablet. Scans were performed, on average, 3.0 years post-trial for the CEE + MPA trial and 1.4 years post-trial for the CEE-Alone trial; average on-trial follow-up intervals were 4.0 years for CEE + MPA and 5.6 years for CEE-Alone.
Study Women’s Health Initiative Memory Study
Study Website WHIMS
Data Descriptor Paper https://doi.org/10.1212/01.wnl.0000339037.76336.cf
DUA https://www.whi.org/md/DUA
Country/Region USA
Disease Tag alzheimers;aging
Age (mean ± SD)
(Baseline) 		69.6 ± 3.6
Age Range
(Baseline) 		63-79
% Female 100
CUBIC Project /cbica/projects/whims
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 1430
N MR Sessions 2160
Diagnoses
AD
Value V01 V02
nan 1286 202
CN 132 525
DLMUSE (v1.0.7)
(2158/2158 complete)
/cbica/projects/whims/Pipelines/WHIMS_DLMUSE_2025/Results/DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(2158/2158 complete)
/cbica/projects/whims/Pipelines/WHIMS_3.5D_DLICV_MASK_2023/Protocols/RAVENS
DLWMLS (v0.1.0)
(2069/2069 complete)
/cbica/projects/whims/Pipelines/WHIMS_DLWMLS_2025/Results/WHIMS_DLWMLS_DLMUSE_Segmented_Volumes.csv
Non-Imaging Data
/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/WHIMS

Raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/dictionaries/WHIMS

Data dictionary of raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv

Data consolidated and harmonized in 2020.

This study: subset with df[df.Study == 'WHIMS']

README: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/README.md

Release Notes: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/Release_Notes.md

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'WHIMS']


Funding
The Women’s Health Initiative Memory Study (WHIMS), an ancillary study to the Women’s Health Initiative (WHI) funded by the National Institutes of Health, is supported through funding by Wyeth-Ayerst Laboratories.