About the dataset

Primary description: Alzheimers prevention cohort

The Pre-symptomatic Evaluation of Experimental or Novel Treatments for AD (PREVENT-AD) is an observational study of cognitively unimpaired participants with a sibling or family member who has or had Alzheimer’s disease. N= 349 study participants were enrolled at McGill University from the year 2010, some of whom participated in a clinical trial for an anti-inflammatory drug, naproxen sodium. Data collection includes longitudinal MR imaging, CSF biomarker and genetic assays, and cognitive and health screenings. Data is publicly available via [https://openpreventad.loris.ca/].
Study Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease
Study Website PreventAD
Data Descriptor Paper https://doi.org/10.1016/j.nicl.2021.102733
DUA https://openpreventad.loris.ca/
Country/Region Canada
Disease Tag alzheimers
Age (mean ± SD)
(Baseline) 		63.6 ± 5.0
Age Range
(Baseline) 		55.17-84.25
% Female 70.8
CUBIC Project /cbica/projects/Prevent_AD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 344
N MR Sessions 1559
Diagnoses
AD
Value V01 V02 V03 V04 V05 V06
CN 345 271 216 184 127 54
MCI 1 2 4 6 3
DLMUSE (v1.0.7)
(1215/1215 complete)
/cbica/projects/Prevent_AD/Pipelines/PreventAD_DLMUSE_2025/Results/DLMUSE/DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(1215/1215 complete)
/cbica/projects/Prevent_AD/Pipelines/PreventAD_3.5D_DLICV_MASK_2023/Protocols/RAVENS
fMRIPrep (23.1.3)
(305/1559 complete)
/cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/Protocols
/opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/Data/BIDS \ /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/Protocols \ participant \ --participant-label 1000173 \ --skip-bids-validation \ --fs-license-file /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/license.txt \ --fs-no-reconall \ --output-spaces MNI152NLin2009cAsym:res-2 \ --debug all
XCP-D (0.7.1rc6)
(299/1559 complete)
/cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/Protocols/XCP
/usr/local/miniconda/bin/xcp_d \ /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/Protocols \ /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/Protocols/XCP \ participant \ --participant-label 1000173 \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024 \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/projects/Prevent_AD/Pipelines/PreventAD_fMRI_2024/license.txt
Non-Imaging Data
/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/PreventAD

Raw data downloaded from source.

https://github.com/conpdatasets/preventad-registered

Data dictionary of raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv

Data consolidated and harmonized in 2020.

This study: subset with df[df.Study == 'PreventAD']

README: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/README.md

Release Notes: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/Release_Notes.md

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'PreventAD']


Funding
The PREVENT-AD study was funded through McGill University, the FRQ-S, the CIHR, Pfizer Canada, Brain Canada, the Alzheimer’s Society of Canada, the Canada Fund for Innovation, the J.L. Levesque Foundation, and the Lemaire Foundation.