About the dataset

Primary description: Depression treatment response

The Canadian Biomarker Integration Network in Depression (CAN-BIND), funded by the Ontario Brain Institute, involves an 8-week treatment protocol of the selective serotonin reuptake inhibitor (SSRI) escitalopram, followed with 8-weeks of aripiprazole (if inadequate treatment response, <50% depressive symptom reduction). Scans were obtained at baseline, two weeks, and eight weeks for both the healthy participants those with major depressive disorder (MDD). For more information, see https://doi.org/10.1186/s12888-022-04509-7.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.
Study Canadian Biomarker Integration Network in Depression
Study Website CANBIND
Data Descriptor Paper https://pmc.ncbi.nlm.nih.gov/articles/PMC6606427/
DUA https://indocconsortium.atlassian.net/wiki/spaces/JSDNXT/pages/3015804901/CAN-BIND+Baseline+Data+Release+Dashboard+-+Data+Request+Walkthrough+Guide
Country/Region Canada
Disease Tag depression
Age (mean ± SD) 34.2 ± 12.0
Age Range 18-61
% Female 64.1
CUBIC Project /cbica/projects/MultisiteMD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 309
N MR Sessions 309
DLMUSE
(310/310 complete)
/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/CANBIND/Results/CANBIND_DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(307/307 complete)
/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/CANBIND
fMRIPrep (23.1.3)
(268/309 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Protocols
/opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Data/CAM/ \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Protocols/CAM \ participant \ --participant_label 0002 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/license.txt \ --fs-no-reconall \ --use-syn-sdc warn \ --output-spaces MNI152NLin2009cAsym:res-2 \ --debug all
XCP-D (0.7.1rc6)
(267/309 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Protocols/XCP/
/usr/local/miniconda/bin/xcp_d \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Protocols/CAM \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Protocols/XCP/CAM/ \ participant \ --participant_label 0002 \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/Protocols/ \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/CANBIND/Pipelines/CANBIND_fMRI_2024/license.txt
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

https://portal.conp.ca/dataset?id=projects%2Fbraincode_CAN-BIND_Biomarkers_for_Depression_Baseline_Data_Release

Data dictionary of raw data downloaded from source.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'CANBIND']


Funding
CAN-BIND is an Integrated Discovery Program carried out in partnership with, and with financial support from, the Ontario Brain Institute, an independent nonprofit corporation funded partially by the Ontario government. Additional funding is provided by the Canadian Institutes of Health Research, Lundbeck, Bristol-Myers Squibb and Servier.