Wisconsin Registry for Alzheimer’s Prevention
About the dataset
Primary description: Alzheimer’s risk in middle-aged adults
The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is a longitudinal observational study of cognitively unimpaired adults. Participants are primarily the healthy children of late-onset Alzheimer’s Disease patients at the Memory Assessment Clinic at the University of Wisconsin-Madison. Since 2001, WRAP has followed 1,561 subjects at bi-annual assessments, including molecular PET and structural MR imaging, CSF collection, laboratory tests, genetic screening, cognitive testing, and self-reported histories of lifestyle and health.
| Study | Wisconsin Registry for Alzheimer’s Prevention | |||||||||||||||||||||||||||||||||||||||||
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| Study Website | WRAP | |||||||||||||||||||||||||||||||||||||||||
| Data Descriptor Paper | https://doi.org/10.1016/j.dadm.2017.11.007 | |||||||||||||||||||||||||||||||||||||||||
| DUA | https://redcap.medicine.wisc.edu/surveys/?s=T9XK8EEN3Y | |||||||||||||||||||||||||||||||||||||||||
| Country/Region | USA | |||||||||||||||||||||||||||||||||||||||||
| Disease Tag | alzheimers;aging | |||||||||||||||||||||||||||||||||||||||||
| Age (mean ± SD)
(Baseline) |
61.7 ± 6.2 | |||||||||||||||||||||||||||||||||||||||||
| Age Range
(Baseline) |
45.4-77.7 | |||||||||||||||||||||||||||||||||||||||||
| % Female | 71.3 | |||||||||||||||||||||||||||||||||||||||||
| CUBIC Project | /cbica/projects/PreclinicalAD |
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| PI for CUBIC Access Approval | Christos Davatzikos | |||||||||||||||||||||||||||||||||||||||||
| N Subjects | 272 | |||||||||||||||||||||||||||||||||||||||||
| N MR Sessions | 735 | |||||||||||||||||||||||||||||||||||||||||
| Diagnoses |
AD
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DLMUSE
(v1.0.7)
(735/735 complete) |
/cbica/projects/PreclinicalAD/PAC_Studies/WRAP/Pipelines/WRAP_DLMUSE_2025/Results/DLMUSE_Volumes.csv
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RAVENS
(DRAMMS-1.4.1)
(735/735 complete) |
/cbica/projects/PreclinicalAD/PAC_Studies/WRAP/Pipelines/WRAP_3.5D_2022_DLICV_MASK/Protocols/RAVENS
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DLWMLS
(v0.1.0)
(715/715 complete) |
/cbica/projects/PreclinicalAD/PAC_Studies/WRAP/Pipelines/WRAP_DLWMLS_2025/Results/WRAP_DLWMLS_DLMUSE_Segmented_Volumes.csv
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| Non-Imaging Data |
/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/WRAP
Raw data downloaded from source. /cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/dictionaries/WRAP
Data dictionary of raw data downloaded from source. /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv
Data consolidated and harmonized in 2020. This study: subset with README: Release Notes: /cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv
Data consolidated and harmonized in 2026. This study: subset with |
Funding
The WRAP study was supported by R01 AG027161 and R01 AG021155. This study was supported in part by the National Institutes of Health (NIH) grant numbers 5R01AG080821, 1R01AG085571 and 5R01AG083865.