About the dataset

Primary description: Imaging genetics consortium

The study is part of the PHENOM consortium. For more information, see: https://doi.org/10.1038/s41380-023-02069-0 and https://doi.org/10.1093/brain/awaa025. The PHENOM (Psychosis Heterogeneity Evaluated Via Dimensional Neuroimaging) consortium is an international consortium pooling MRI and clinical data across several institutions world-wide. The focus on the consortium is to study the use of machine learning and MRI as a means for deriving personalized imaging signatures of schizophrenia, and of predicting future clinical progression. An associated goal is to use state of the art weakly supervised machine learning methods to dissect neuroanatomical heterogeneity in psychosis. In addition to offering healthy control subjects at younger ages, this consortium helps establish imaging signatures of psychosis into NiChart.
Study Enhancing Neuro Imaging Genetics through Meta-Analysis
Data Descriptor Paper https://doi.org/10.1038/s41380-023-02069-0
DUA https://enigma.ini.usc.edu/ongoing/enigma-schizophrenia-working-group
Country/Region International
Disease Tag psychosis
Age (mean ± SD) 37.8 ± 13.1
Age Range 16-86
% Female 48.1
CUBIC Project /cbica/projects/PsychAnalysis
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 370
N MR Sessions 370
DLMUSE (v1.0.7)
(365/365 complete)
/cbica/projects/PsychAnalysis/Pipelines/PHENOM_DLMUSE_2025/Enigma/Results/Enigma_DLMUSE_Volumes.csv
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'Enigma']


Funding
Funding for ENIGMA comes from a variety of sources. Core funding for the ENIGMA Center for Worldwide Medicine Imaging and Genomics was provided as part of the 2014 NIH Big Data to Knowledge (BD2K) Initiative under U54EB020403 (PI: Paul Thompson) to support big data analytics, management and distribution of programs.

Support for data collection and site-level analysis is provided by individual group studies from around the world including Africa, Asia, Australia, Europe, North America, and South America. These include: NHMRC, DCRC, BMBF, Swedish Research Council, German Ministry of Cultural Affairs, Social Ministry of the Federal State of Mecklenburg–West Pomerania, NGFN, Siemens, ISCIII, SENY Fundació, NOW, BBMRI-NL, CBF, Hersenstichting Nederland, Alzheimer’s Australia Dementia Research Foundation, Autism Speaks, NIMH, NIBIB, NICHD, NINDS, NIA