About the dataset

The Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) is a multisite randomized placebo-control clinical trial consisting of two stages of double-blind treatment. Stage 1 participants were randomized to receive placebo or sertraline for eight weeks. Stage 2 continued for eight weeks if participants display meaningful improvement on the Clinical Global Improvement (CGI) scale. Those with minimal improvement transitioned to bupropion. MRI scans were obtained at baseline in both medication-free individuals and those with MDD and healthy controls. For more information, see https://doi.org/10.1186/s12888-022-04509-7.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.
Study Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care
Study Website EMBARC
Data Descriptor Paper https://www.sciencedirect.com/science/article/pii/S0022395616300395
DUA https://nda.nih.gov/edit_collection.html?id=2199
Disease Tag depression
Age (mean ± SD) 37.1 ± 13.5
Age Range 18-65
% Female 65.2
CUBIC Project /cbica/projects/MultisiteMD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 329
N MR Sessions 329
DLMUSE
(330/330 complete)
/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/EMBARC/Results/EMBARC_DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(329/329 complete)
/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/EMBARC
fMRIPrep (23.1.3)
(320/329 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Protocols/
opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Data/CU/ \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Protocols/CU/ \ participant \ --participant_label 0009 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/license.txt \ --fs-no-reconall \ --use-syn-sdc warn \ --output-spaces MNI152NLin2009cAsym:res-2 \ --debug all
XCP-D (0.7.1rc6)
(318/329 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Protocols/XCP/
/usr/local/miniconda/bin/xcp_d \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Protocols/CU \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Protocols/XCP/CU/ \ participant \ --participant_label 0009 \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/Protocols/ \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/EMBARC/Pipelines/EMBARC_fMRI_2024/license.txt
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

https://nda.nih.gov/edit_collection.html?id=2199

Data dictionary of raw data downloaded from source.


Funding
The EMBARC study was supported by the National Institute of Mental Health of the National Institutes of Health under award numbers U01MH092221 (Trivedi, M.H.) and U01MH092250 (McGrath, P.J., Parsey, R.V., Weissman, M.M.)