Coronary Artery Risk Development in Young Adults

About the dataset

Primary description: Cardiovascular risk in young adults

The Coronary Artery Risk Development in Young Adults (CARDIA) is an ongoing longitudinal study of the development and trajectories of cardiovascular disease in a bi-racial population-based cohort. Data collection began in 1985 with follow-up visits in 5-year intervals, at four sites in the USA. Brain MRI began in CARDIA year 25 and continued in year 30 and year 35, with a subset of less than 1,000 of over 5,000 subjects participating in the brain MRI protocol. Non-imaging data from the CARDIA study is available through the NHLBI’s BIOLINCC [https://biolincc.nhlbi.nih.gov/studies/cardia/].

Study Coronary Artery Risk Development in Young Adults

Study Website CARDIA

Data Descriptor Paper https://doi.org/10.1161/JAHA.117.006750

DUA https://biolincc.nhlbi.nih.gov/studies/cardia/

Country/Region USA

Disease Tag cardiovascular

Age (mean ± SD)
(Baseline) 51.2 ± 4.0

Age Range
(Baseline) 42-61

% Female 52.8

CUBIC Project /cbica/projects/cardia

PI for CUBIC Access Approval Christos Davatzikos

N Subjects 882

N MR Sessions 2293

Diagnoses

Value	V01	V02
CN	892	487

Hypertension

Value	V01	V02
Normal	464	267
Stage2	322	174
Stage1	106	46

Diabetes

Value	V01	V02
Normal	516	285
Prediabetic	268	154
Diabetic	108	48

Depression

Value	V01	V02
Negative/absent	691	386
Positive/present	198	98
nan	3	3

Hyperlipidemia

Value	V01	V02
Negative/absent	618	317
Positive/present	249	155
nan	25	15

DLMUSE (v1.0.7)
(2284/2284 complete)

/cbica/projects/cardia/Pipelines/CARDIA_DLMUSE_2025/Results/DLMUSE_Volumes.csv

RAVENS (DRAMMS-1.4.1)
(1405/1405 complete)

/cbica/projects/cardia/Pipelines/CARDIA_3.5D_2020/Protocols/RAVENS

DLWMLS (v0.1.0)
(2277/2277 complete)

/cbica/projects/cardia/Pipelines/CARDIA_DLWMLS_2025/Results/CARDIA_DLWMLS_DLMUSE_Segmented_Volumes.csv

fMRIPrep (23.1.3)
(1164/2293 complete)

/cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/Protocols

/opt/conda/envs/fmriprep/bin/fmriprep \
  /cbica/comp_space/cardia/Data/BIDS/ \
  /cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/Protocols/b00 \
  participant \
  --participant_label sub-10005 \
  --fs-license-file /cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/license.txt \
  --work /cbica/comp_space/cardia/ \
  --fs-no-reconall \
  --use-syn-sdc warn \
  --output-spaces MNI152NLin2009cAsym:res-2 \
  --debug all

XCP-D (0.7.1rc6)
(692/2293 complete)

/cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/Protocols/XCP

/usr/local/miniconda/bin/xcp_d \
  /cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/Protocols/b00 \
  /cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/Protocols/XCP/b00 \
  participant \
  --participant_label 10386 \
  --input-type fmriprep \
  -p 36P \
  --work-dir /cbica/comp_space/cardia \
  --motion-filter-type lp \
  --band-stop-min 6 \
  --motion-filter-order 4 \
  --despike \
  --fd-thresh 0 \
  --lower-bpf 0.01 \
  --upper-bpf 0.08 \
  --bpf-order 2 \
  --head-radius auto \
  --dummy-scans auto \
  --min-coverage 0.5 \
  --smoothing 0 \
  --fs-license-file /cbica/projects/cardia/Pipelines/CARDIA_fMRI_2025/license.txt

Non-Imaging Data

/cbica/projects/ISTAGING/Pipelines/ClinicalDataConsolidation_201911/Data/External_Data/CARDIA

Raw data downloaded from source.

https://biolincc.nhlbi.nih.gov/media/studies/cardia/data_dictionary/CARDIA_2023a.pdf

Data dictionary of raw data downloaded from source.

/cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/istaging.csv

Data consolidated and harmonized in 2020.

This study: subset with df[df.Study == 'CARDIA']

README: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/README.md

Release Notes: /cbica/projects/ISTAGING/Pipelines/ISTAGING_Data_Consolidation_2020/v2.0/Release_Notes.md

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'CARDIA']

Funding
The CARDIA (Coronary Artery Risk Development in Young Adults) study — including its brain MRI substudy — is primarily supported by the U.S. National Institutes of Health (NIH), specifically through the National Heart, Lung, and Blood Institute (NHLBI).