About the dataset

STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. For more information, see https://doi.org/10.1186/s12888-022-04509-7.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.
Study STratifying Resilience and Depression Longitudinally
Study Website STRADL
Data Descriptor Paper https://pubmed.ncbi.nlm.nih.gov/35237729/
DUA Please contact Dr. Christos Davatzikos to obtain the DUA for the derived data and request an introduction to the study PI to obtain the DUA for the raw data.
Disease Tag depression
Age (mean ± SD) 59.6 ± 10.1
Age Range 26-84
% Female 58.6
CUBIC Project /cbica/projects/MultisiteMD
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 1080
N MR Sessions 1080
RAVENS (DRAMMS-1.4.1)
(1080/1080 complete)
/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/STRADL
fMRIPrep (23.1.3)
(769/1080 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Protocols
/opt/conda/envs/fmriprep/bin/fmriprep \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Data/Aberdeen/ \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Protocols/Aberdeen/ \ participant \ --participant_label 0001 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/license.txt \ --skip-bids-validation \ --fs-no-reconall \ --use-syn-sdc warn \ --output-spaces MNI152NLin2009cAsym:res-2 \ --debug all
XCP-D (0.7.1rc6)
(1034/1080 complete)
/cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Protocols/XCP/
/usr/local/miniconda/bin/xcp_d \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Protocols/Aberdeen/ \ /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Protocols/XCP/Aberdeen/ \ participant \ --participant_label 0001 \ --input-type fmriprep \ -p 36P \ --work-dir /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/Protocols/Aberdeen/ \ --motion-filter-type lp \ --band-stop-min 6 \ --motion-filter-order 4 \ --despike \ --fd-thresh 0 \ --lower-bpf 0.01 \ --upper-bpf 0.08 \ --bpf-order 2 \ --head-radius auto \ --dummy-scans auto \ --min-coverage 0.5 \ --smoothing 0 \ --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/STRADL/Pipelines/STRADL_fMRI_2024/license.txt
Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.


Funding
MC_PC_17209/MRC_/Medical Research Council/United Kingdom MC_PC_MR/R01910X/1/MRC_/Medical Research Council/United Kingdom MC_UU_00011/7/MRC_/Medical Research Council/United Kingdom MR/S035818/1/MRC_/Medical Research Council/United Kingdom