Longitudinal Imaging of Brain & Risk Study

About the dataset

The Laureate Institute for Brain Research (LIBR) is combined of two studies of those with first episode and recurrent major depressive disorder (MDD) and matched controls. For more information, see https://doi.org/10.1186/s12888-022-04509-7.

The study is part of the COORDINATE-MDD consortium. For more information, see: https://doi.org/10.1038/s44220-023-00187-w.

Study Longitudinal Imaging of Brain & Risk Study

Data Descriptor Paper https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2727131

DUA Please contact Dr. Christos Davatzikos to obtain the DUA for the derived data and request an introduction to the study PI to obtain the DUA for the raw data.

Disease Tag depression

Age (mean ± SD) 32.0 ± 10.5

Age Range 18-55

% Female 62.7

CUBIC Project /cbica/projects/MultisiteMD

PI for CUBIC Access Approval Christos Davatzikos

LIBR-BodurkaR01

Diagnoses

Depression

Value	V01
0.0	82
1.0	79
nan	14

N Subjects 175

N MR Sessions 175

DLMUSE (v1.0.7)
(175/175 complete)

/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/LIBR-BodurkaR01/Results/LIBR-BodurkaR01_DLMUSE_Volumes.csv

RAVENS (DRAMMS-1.4.1)
(175/175 complete)

/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/LIBR-BodurkaR01

fMRIPrep (23.1.3)
(175/175 complete)

/cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Protocols

/opt/conda/envs/fmriprep/bin/fmriprep \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Data/ \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Protocols/ \
  participant \
  --participant_label AA003 \
  --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/license.txt \
  --fs-no-reconall \
  --use-syn-sdc warn \
  --output-spaces MNI152NLin2009cAsym:res-2 \
  --debug all

XCP-D (0.7.1rc6)
(175/175 complete)

/cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Protocols/XCP

/usr/local/miniconda/bin/xcp_d \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Protocols/ \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Protocols/XCP/ \
  participant \
  --participant_label AA003 \
  --input-type fmriprep \
  -p 36P \
  --work-dir /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/Protocols/ \
  --motion-filter-type lp \
  --band-stop-min 6 \
  --motion-filter-order 4 \
  --despike \
  --fd-thresh 0 \
  --lower-bpf 0.01 \
  --upper-bpf 0.08 \
  --bpf-order 2 \
  --head-radius auto \
  --dummy-scans auto \
  --min-coverage 0.5 \
  --smoothing 0 \
  --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-BodurkaR01/Pipelines/LIBR-BodurkaR01_fMRI_2024/license.txt

Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'LIBR-BodurkaR01']

LIBR-Svitz

Diagnoses

Depression

Value	V01
0.0	60
1.0	53
nan	4

N Subjects 121

N MR Sessions 121

DLMUSE (v1.0.7)
(121/121 complete)

/cbica/projects/MultisiteMD/Pipelines/MultisiteMD_DLMUSE_2025/LIBR-SvitzK01/Results/LIBR-SvitzK01_DLMUSE_Volumes.csv

RAVENS (DRAMMS-1.4.1)
(121/121 complete)

/cbica/projects/MultisiteMD/Pipelines/CoordinateMD_3.5D_2020/Protocols/RAVENS/LIBR-SvitzK01

fMRIPrep (23.1.3)
(121/121 complete)

/cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Protocols

/opt/conda/envs/fmriprep/bin/fmriprep \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Data/ \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Protocols/ \
  participant \
  --participant_label AA343 \
  --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/license.txt \
  --fs-no-reconall \
  --use-syn-sdc warn \
  --output-spaces MNI152NLin2009cAsym:res-2 \
  --debug all

XCP-D (0.7.1rc6)
(121/121 complete)

/cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Protocols/XCP

/usr/local/miniconda/bin/xcp_d \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Protocols/ \
  /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Protocols/XCP/ \
  participant \
  --participant_label AA343 \
  --input-type fmriprep \
  -p 36P \
  --work-dir /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/Protocols/ \
  --motion-filter-type lp \
  --band-stop-min 6 \
  --motion-filter-order 4 \
  --despike \
  --fd-thresh 0 \
  --lower-bpf 0.01 \
  --upper-bpf 0.08 \
  --bpf-order 2 \
  --head-radius auto \
  --dummy-scans auto \
  --min-coverage 0.5 \
  --smoothing 0 \
  --fs-license-file /cbica/projects/MultisiteMD/CoordinateMD_Studies/LIBR-SvitzK01/Pipelines/LIBR-SvitzK01_fMRI_2024/license.txt

Non-Imaging Data

Contact Mathilde Antoniades to request access to the non-imaging data.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'LIBR-Svitz']

Funding
This research was supported by the National Institute of Mental Health (grant K23MH108707 to Dr Aupperle and grant R21MH113871 to Dr Savitz); the Laureate Institute for Brain Research, National Institute of General Medical Sciences (grant P20GM121312 to Dr Paulus); and the Brain and Behavior Research Foundation (National Alliance for Research on Schizophrenia & Depression grant YI 23850 to Dr Savitz).