About the dataset

Primary description: National AD data coordinating center

The National Alzheimer’s Coordinating Center (NACC) is the central repository for data collected from several Alzheimer’s Disease Research Centers (ADRCs) across the US. Since 2005, the center has aggregated longitudinal clinical, cognitive, demographic, and diagnostic data using its Uniform Data Set (UDS). Imaging and biomarker data are integrated using the SCAN protocol and includes MRI and PET data. The neuropathology dataset includes aspects of vascular pathology, TDP-43, Lewy bodies, and other comorbid pathologies.
Study National Alzheimer’s Coordinating Center
Study Website NACC
Data Descriptor Paper https://pubmed.ncbi.nlm.nih.gov/15592144/
DUA https://naccdata.org/requesting-data/submit-data-request
Country/Region USA
Disease Tag alzheimers
Age (mean ± SD)
(Baseline) 		71.3 ± 10.2
Age Range
(Baseline) 		21-100
% Female 58.7
CUBIC Project /cbica/projects/NIAGADS
PI for CUBIC Access Approval Christos Davatzikos
N Subjects 5004
N MR Sessions 6543
Diagnoses
AD
Value V01 V02 V03 V04 V05 V06 V07 V08 V09
CN 3402 985 301 51 11 4 2 1 1
MCI 1521 254 49 18 3 2
AD 998 153 37 12 2 2
nan 987 289 90 28 5 2 1 1
DLMUSE (v1.0.7)
(6543/6543 complete)
/cbica/projects/NIAGADS/ADSP/Pipelines/ADSP_NACC_Release_V1_DLMUSE_2025/Results/DLMUSE_Volumes.csv
RAVENS (DRAMMS-1.4.1)
(6543/6543 complete)
/cbica/projects/NIAGADS/ADSP/Pipelines/ADSP_NACC_Release_V1_3.5D_2023_DLICV_MASK/Protocols/RAVENS
Non-Imaging Data
/cbica/projects/NIAGADS/ADSP/Data/DemogClinScanner_Data/InitDownloaded

Raw data downloaded from source.

https://vmacdata.org/adsp-phc/data/data-dictionary

Data dictionary of raw data downloaded from source.

/cbica/home/harmang/for_others/final_combined_istaging_withMUSE.csv

Data consolidated and harmonized in 2026.

This study: subset with df[df.Study == 'NACC']


Funding
The NACC database is funded by NIA/NIH Grant U24 AG072122. NACC data are contributed by the NIA-funded ADRCs: P30 AG062429 (PI James Brewer, MD, PhD), P30 AG066468 (PI Oscar Lopez, MD), P30 AG062421 (PI Bradley Hyman, MD, PhD), P30 AG066509 (PI Thomas Grabowski, MD), P30 AG066514 (PI Mary Sano, PhD), P30 AG066530 (PI Helena Chui, MD), P30 AG066507 (PI Marilyn Albert, PhD), P30 AG066444 (PI David Holtzman, MD), P30 AG066518 (PI Lisa Silbert, MD, MCR), P30 AG066512 (PI Thomas Wisniewski, MD), P30 AG066462 (PI Scott Small, MD), P30 AG072979 (PI David Wolk, MD), P30 AG072972 (PI Charles DeCarli, MD), P30 AG072976 (PI Andrew Saykin, PsyD), P30 AG072975 (PI Julie A. Schneider, MD, MS), P30 AG072978 (PI Ann McKee, MD), P30 AG072977 (PI Robert Vassar, PhD), P30 AG066519 (PI Frank LaFerla, PhD), P30 AG062677 (PI Ronald Petersen, MD, PhD), P30 AG079280 (PI Jessica Langbaum, PhD), P30 AG062422 (PI Gil Rabinovici, MD), P30 AG066511 (PI Allan Levey, MD, PhD), P30 AG072946 (PI Linda Van Eldik, PhD), P30 AG062715 (PI Sanjay Asthana, MD, FRCP), P30 AG072973 (PI Russell Swerdlow, MD), P30 AG066506 (PI Glenn Smith, PhD, ABPP), P30 AG066508 (PI Stephen Strittmatter, MD, PhD), P30 AG066515 (PI Victor Henderson, MD, MS), P30 AG072947 (PI Suzanne Craft, PhD), P30 AG072931 (PI Henry Paulson, MD, PhD), P30 AG066546 (PI Sudha Seshadri, MD), P30 AG086401 (PI Erik Roberson, MD, PhD), P30 AG086404 (PI Gary Rosenberg, MD), P20 AG068082 (PI Angela Jefferson, PhD), P30 AG072958 (PI Heather Whitson, MD), P30 AG072959 (PI James Leverenz, MD).